The Cardiovascular Spectrum of Adverse Drug Reactions
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Undesired sequelae of pharmacologic agents encom-pass a wide range of adverse cardiovascular effects, including proarrhythmic, atherogenic, myopathic and valvular consequences.
The Cardiovascular
Spectrum of Adverse Drug Reactions
Undesired
sequelae of pharmacologic agents encom-pass a wide range of adverse
cardiovascular effects, including proarrhythmic, atherogenic, myopathic and
valvular consequences (Table 41.1). In this chapter, we will focus on three
agents, each demonstrating a different undesired clinical cardiovascular drug
effect. The mode of identification and subsequent scientific investigators and
regulatory steps are summarized for dofetilide’s proarrhythmic characteristics,
cardiac valvular effects of appetite suppressants and oestro-gen’s venous
thrombogenicity.
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