Tetracyclines have a ring system of four linear annelated six-membered rings and are characterized by a common octahydronaphthacenes skeleton.
Tetracyclines
have a ring system of four linear annelated six-membered rings and are
characterized by a common octahydronaphthacenes skeleton. They are potent,
broad-spectrum antibacterial agents effective against gram-positive and
gram-negative aerobic and anaerobic bacteria. As a result, the tetracyclines
are drugs of choice or well-accepted alternatives for a variety of infectious
diseases. Among these, they also play a role in the treatment of sexually
transmitted and gonococcal diseases, urinary tract infections, bronchitis, and
sinusitis remain prominent.
The majority
of the marketed tetracyclines (tetracycline, chlorotetracycline,
oxytetracycline, and demeclocycline) are naturally occurring compounds obtained
by the fermentation of Streptomyces spp. broths.
The semisynthetic tetracyclines (methacycline, doxycycline, minocycline) have
the advantage of longer duration of antibacterial action. However, all these
tetracyclines exhibit a similar proļ¬le in terms of antibacterial potency. In
general, their activity encompasses many strains of gram-negative E. coli, Proteus, Klebsiella, Enterobacter,
Niesseria, and Serratia spp., as
well as gram-negative Streptococci and
Staphylococci of particular interest
is the potency of tetracylines against Haemophilus,
Legionella, Chlamydia, and Mycoplasma.
I.Natrual tetracyclines (biosynthetic)
II. Semisynthetic
tetracyclines
III. Protetracyclines
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