Serratiopeptidase

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Chapter: Pharmacognosy and Phytochemistry : Enzymes and Protein Drugs

Serratiopeptidase is a proteolytic enzyme isolated from nonpathogenic enterobacteria Serratia E 15. It is also produced by the larval form of the silk moth.


SERRATIOPEPTIDASE

 

 

Synonym

 

Serrapeptase, serratiopeptidase.

 

Biological Source

 

Serratiopeptidase is a proteolytic enzyme isolated from nonpathogenic enterobacteria Serratia E 15. It is also produced by the larval form of the silk moth.

 

Preparation

 

Serratiopeptidase is produced by fermentation technology by using nonpathogenic enterobacteria species such as Serratia E 15. The larvae of silk moth produce this enzyme in their intestine to break down cocoon walls. It can thus be obtained from the silk moth larvae.

 

Characteristics

 

Serratiopeptidase is very much vulnerable to degradation in the acidic pH. When consumed in unprotected tablet or capsule, it is destroyed by acid in stomach. However enteric coated tablets facilitate its absorption through intestine. One unit of the enzyme hydrolyses casein to produce colour equivalent to 1.0 μmol of tyrosine per minute at pH 7.5 and 35°C.

 

Chemical Constituents

 

Serratiopeptidase is a proteolytic enzyme of protease type XXVI. The preparation contains 7.1 units/mg solid.

 

Uses

 

Serratiopeptidase is the most widely prescribed antiinflammatory enzyme in developed countries and also in India. It eliminates inflammatory oedema and swelling, accelerate liquefaction of pus and sputum, and enhance the action of antibodies. It is also used as a fast wound healing agent. It is proving to be a superior alternative to the nonsteroidal antiinflammatory drugs traditionally used to treat rheumatoid arthritis and osteoarthritis. It has wide ranging applications in trauma surgery, plastic surgery, respiratory medicine, obstetric and gynaecology.

 

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