SAR of Succinimides
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The activity of antiepileptic agents, such as the oxazolidine 2,4-dione with substituted succinamides was logical choice for synthesis and evaluation.
SAR of Succinimides The activity of antiepileptic agents, such as the oxazolidine 2,4-dione with substituted succinamides (CH2 replace O) was logical choice for synthesis and evaluation. N-demethylation occurs to yield the putative active metabolite. Both phensuximide and the N-demethyl metabolite are inactivated by p-hydroxylation and conjugation.
