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Chapter: Medicinal Chemistry : Antifungal Agents

Antifungal Agents - Peptides\proteins : i. L-Norvalyl—FMIP ii. cis Pentacin

Antifungal Agents - Synthesis and Drug Profile


Examples—L-Norvalyl FMIP, Cispentacin

i. L-Norvalyl—FMIP

Mode of action: The inhibitors of glucosamine-6-phosphate synthase delivered through peptide transport systems have been reported as having anticandidal activity.

ii. cis Pentacin

Properties and uses: It is dipeptide analogue that is shown in vitro and in vivo activity against C. albicans.

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