Penicillinase Susceptible Penicillins

| Home | | Medicinal Chemistry |

Chapter: Medicinal Chemistry : Antibiotics

Penicillinase Susceptible Penicillins : Penicillin-V

Penicillin - Synthesis and Drug Profile

Penicillinase Susceptible Penicillins

i. Penicillin-V


Properties and uses: Penicillin V is a white, odourless, crystalline powder with slightly bitter taste and soluble in water. It is more resistant to inactivation by gastric juice than penicillin G and better absorbed from the gastro intestinal (GI) tract. Equivalent oral doses provide two or five times greater plasma concentration than penicillin G. Penicillin V is given to treat ‘trench mouth’. It is useful in the treatment of streptococcal pharyngitis, pneumonia, arthritis, meningitis, and endocarditis caused by S. pyrogenes.

Dose: Dose of penicillin V by oral route is 125–500 mg six times daily for 10 days. For prophylaxis of rheumatic fever, the dose is 125–250 mg twice daily.

Assay: It is assayed by adopting liquid chromatography technique.

Contact Us, Privacy Policy, Terms and Compliant, DMCA Policy and Compliant

TH 2019 - 2023; Developed by Therithal info.