Antineoplastic Agents: Hydroxy Urea, Gallium Nitrate, Cisplastin, Carboplatin
Micellaneous
Synthesis
Uses: It is active against melanoma and chronic myelocytic leukaemia.
Ga (NO3)3
. 9H2O
Uses: It is used to treat cancer-related hypocalcaemia.
Synthesis
Properties and uses: Cisplatin is a yellow powder or yellow or
orange-yellow crystals, slightly soluble in water, sparingly soluble in
dimethylformamide, and practically insoluble in alcohol, used in testicular
tumour.
Assay: It is assayed by adopting liquid chromatography technique.
Dosage forms: Cisplatin injection B.P.
Synthesis
Properties and uses: Carboplatin is a colourless crystalline powder,
sparingly soluble in water, very slightly soluble in acetone and alcohol. Food
and Drug Administration (FDA) approved it for treatment of advanced ovarian
cancer. It is cross-resistant with cisplatin in this tumour. Activity also has
been reported in lung cancer, head and neck cancer, and testicular cancer. The
usual dose-limiting toxicity is bone marrow suppression, especially,
thrombocytopenia.
Assay: It is assayed by gravimetric method.
Dosage forms: Carboplatin injection B.P.
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