Hyaluronidase is an enzyme product prepared from mammalian testes which shows the capability of hydrolysing hyaluronic acid like mucopolysaccharides. Skin is considered as the largest store of hyaluronidase in the body.
HYALURONIDASE
Synonym
Spreading factor, hyalase.
Biological Source
Hyaluronidase is an enzyme product prepared from mammalian
testes which shows the capability of hydrolysing hyaluronic acid like
mucopolysaccharides. Skin is considered as the largest store of hyaluronidase
in the body.
Preparation
Hyaluronidase enzyme is found in type-II Pneumococci, in group A and C haemolytic
streptococci, S. aureus, and Clostridium
welchii. Hyaluronidase manufacturers define their product in terms of turbidity reducing (TR) units or in
viscosity units. Prepared solution for injection usually contains 150 TR units
or 500 viscosity units dissolved in 1 ml. of isotonic NaCl solution.
Characteristics
Hyaluronidase for injection consists of not more than 0.25 μg of tyrosine for each USP hyaluronidase unit. Due to its action on hyaluronic acid, it promotes diffusion and hastens
absorption of subcutaneous infusions. It depolymerises and catalyses hyaluronic
acid and similar hexosamine-containing polysaccharides.
Chemical Constituents
Hyaluronidases are a group of enzymes such as
4-lycano-hydrolase, hyaluronate 3-glycanohydrolase, and hyaluronate lyase. They
are mucopeptides composed of alternating N-acetylglucosamine and glucuronic
acid residues. Hyaluronidases catalyse the breakdown of hyaluronic acid.
Uses
Hyaluronidase for injection is used in the conditions of
hypodermoclysis. It is used as a spreading and diffusing agent. It promotes
diffusion, absorption, and reabsorption.
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