1. Barbiturates 2. Hydantoins 3. Oxazolidinedione derivatives 4. Succinimides 5. Phenyl acetyl ureas 6. Benzodiazepines 7. Carbonic anhydrase inhibitors 8. GABA analogues 9. Iminostilbenes 10. Miscellaneous 11. Newer—anticonvulsants
CLASSIFICATION Barbiturates Hydantoins Oxazolidinedione derivatives Succinimides Phenyl acetyl ureas Benzodiazepines Carbonic anhydrase inhibitors GABA analogues Iminostilbenes Miscellaneous Newer—anticonvulsants Most of the barbiturates are sedatives and hypnotics. Only a few of them show anticonvulsant characters. Three important barbiturates that show anticonvulsant properties are the following: The hydantoins are close structural relatives of barbituric acid, differing due to the lack of C-6 oxo group. The lack of this carbonyl group decreases the acidity. So it is a weaker acid than that of barbiturates. Replacement of the -NH group at position 1 of the hydantoin systems with oxygen atom yields the oxazolidine-2,4-dione system, trimethadione is only clinically used. Drugs used for treating epileptic disorders are listed in Table 9.1 Table 9.1 Drugs used for treating epileptic disorders. Anticonvulsant drugs can be classified as follows: Centrally acting: General anaesthetics, paraldehyde, barbiturates, and diazepam. Acting mainly on the spinal cord: Mephenesin. Peripheral skeletal muscle relaxants: d-Tubocurarine and succinyl choline.i. Barbiturates
ii. Hydantoins
iii. Oxazolidinediones
IV. Succinimides
V. Acetyl urea derivatives or phenyl acetyl ureas
VI. Benzodiazepines
VII. Carbonic anhydrase inhibitors
VIII. Gamma amino butyric acid (GABA) analogues
IX. Iminostilbenes
X. Miscellaneous
XI .Newer anticonvulsants
Pharmalocogical Classification
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