Antihistamines - > H1-antagonists with classical structure - > Antazoline (Antistine) - Synthesis and Drug Profile
Antazoline (Antistine)
Synthesis
Properties and uses: Antazoline hydrochloride is a white crystalline
powder, sparingly soluble in water, soluble in alcohol, and slightly soluble in
methylene chloride. The phosphate salt is soluble in water, bitter taste. It is
used for the treatment of rhinitis and conjunctivitis.
Assay: Dissolve the sample in alcohol and titrate against 0.1 M
alcoholic potassium hydroxide using phenolphthalein as indicator.
Dose: Usual dose is 50–100 mg per day.
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