Amides

Anthelmintics - Synthesis and Drug Profile

Amides

Niclosamide (Niclocide)

Synthesis

Mode of action: Niclosamide is also a potent mollusicide, which is effective against Biomphaloria glabrata, the principle action of the drug may be to inhibit anaerobic phosphorylation of adenosine diphosphate (ADP) by the mitochondria of the parasite, an energy producing process.

Properties and uses: Niclosamide exists as yellowish fine crystals, practically insoluble in water, sparingly soluble in acetone, and slightly soluble in ethanol. It is used as an anthelmintic.

Assay: Dissolve the sample in a mixture of equal volumes of acetone and methanol and titrate with 0.1 M tetrabutylammonium hydroxide. Determine the end point potentiometrically.

Dose: The dose orally to be taken after meals is 2 g chewable tablets.

Dosage forms: Niclosamide tablets B.P.