Antibacterial Sulphonamides : Topically used sulphonamides : i. Mafenide (Sulfamylon) ii. Silver Sulphadiazine iii. Dapsone (Avcosulfon) iv. Solapsone
Uses: It is used in the treatment and cure of gas gangrene. It is also
effective against Clostridium welchii on
topical application.
Dose: Dose is 5% solution of mafenide hydrochloride or mafenide
propionate for topical use.
Synthesis
Uses: It is an effective topical antimicrobial agent, especially,
against Pseudomonas species; it finds
extensive use in burn therapy.
Action and use: Dapsone is a white or slightly yellowish-white
crystalline powder, very slightly soluble in water, soluble in acetone and
dilute mineral acids, sparingly soluble in alcohol. Used as folic acid
synthesis inhibitor in the treatment of leprosy and nocardiosis.
Assay: Dissolve the sample in dilute hydrochloric acid, add potassium
bromide, cool in ice, and titrate against 0.1N sodium nitrate. Determine the
end point electrometrically.
Dose: The dose as a leprostatic is 25 mg twice a week initially for 1
month followed by 25 mg per day each month. As suppressant for dermatitis
herpetiformis the dose is 100–200 mg per day.
Dosage forms: Dapsone tablets B.P.
Synthesis
Synthesis
Uses: It is used in the treatment of leprosy.
Related Topics
TH 2019 - 2024 pharmacy180.com; Developed by Therithal info.