In fact, microorganism invariably refers to the minute living body not perceptible to the naked eyes, especially a bacterium or protozoon.
Pharmaceutical
Microbiology
INTRODUCTION
AND SCOPE
INTRODUCTION
Microbiology
is the — ‘scientific study of the
microorganisms’.
In fact, microorganism invariably refers to the
minute living body not perceptible to the naked eyes, especially a bacterium or
protozoon.
Importantly,
microorganisms may be carried from one host to another as follows :
(a) Animal Sources. Certain
organisms are pathogenic for humans
as well as animals and may be
communicated to humans via direct,
indirect, or intermediary animal hosts.
(b) Airborne. Pathogenic microorganisms in the
respiratory track may be discharged from the mouth or nose into the air and
usually settle on food, dishes or clothing. They may carry infection if they
resist drying.
(c) Contact Infections. Direct
transmission of bacteria from one host to another viz., sexually transmitted diseases (STD).
(d) Foodborne. Food as well as water may
contain pathogenic organisms usually acquired from the handling the food by
infected persons or via fecal or
insect contamination.
(e) Fomites. Inanimate objects e.g., books, cooking utensils, clothing
or linens that can harbor microorganisms and could serve to transport them from
one location to another.
(f) Human Carriers. Persons
who have recovered from an infectious disease do remain carri-ers of the
organism causing the infection and may transfer the organism to another host.
(g) Insects. Insects may be the physical carriers, for instance : housefly (Musca domestica), or act as intermediate
hosts, such as : the Anopheles
mosquito.
(h) Soilborne. Spore-forming organisms in the
soil may enter the body via a cut or
wound. Invariably fruits and vegetables, particularly root and tuber crops,
need thorough cleansing before being eaten raw.
Microbiology is the specific branch of ‘biology’ that essentially deals with the
elaborated inves-tigation of ‘microscopic
organisms’ termed as microbes,
that are composed of only one cell. These are typically either unicellular or multicellular microscopic organisms that are distributed abundantly
both in the living bodies of plants and animals and also in the air, water,
soil, and marine kingdom.
Interestingly,
each and every microbe essentially bear both specific and special
characteristic features that enable it to survive adequately in a wide spectrum
of environments, such as : streams, ponds, lakes, rivers, oceans, ice,
water-borne pipes, hot-springs, gastro-intestinal tract (GIT), roots of plants,
and even in oil wells. In general, the microorganisms are usually characterized
by very typical and extremely high degree of adaptability. Microbes are
invariably distributed over the entire biosphere,
lithosphere, hydrosphere, and above
all the atmosphere.
One may
also define microbiology as — ‘the study of living organisms of microscopic
size, that include essentially
bacteria, fungi, algae, protozoa and the infectious agents at the very
borderline of life which are broadly known as viruses.
It is
mainly concerned with a variety of vital and important aspects, such as :
typical form, inher-ent structure, reproduction, physiological characteristics,
metabolic pathways (viz., anabolism,
and ca-tabolism), and logical classification. Besides, it includes the study of
their :
·
Distribution in nature,
·
Relationship to each other and to other living
organisms,
·
Specific effects on humans, plants, and animals,
and
·
Reactions to various physical and chemical agents.
The
entire domain of microbiology may be
judiciously sub-divided into a plethora of diversified, well-recognized, and
broadly accepted fields, namely :
Bacteriology : the study of organism (bacteria),
Mycology : the study of fungi,
Phycology : the study of algae,
Protozoology : the study of protozoans, and
Virology : the study of viruses.
Advantages : The advantageous fields of
microbiology are essentially the ones enumerated below :
1. Aero-Microbiology — helps in the overall
preservation and preparation of food, food-prone diseases, and their ultimate prevention.
2. Beverage Microbiology — making
of beer, shandy, wine, and a variety of alcoholic bever-ages e.g., whisky, brandy, rum, gin, vodka.
etc.
3. Exomicrobiology — to help
in the exploration of life in the outerspace.
4. Food Microbiology — making
of cheese, yogurt.
5. Geochemical Microbiology — to help
in the study of coal, mineral deposits, and gas forma-tion ; prospecting the
deposits of gas and oil, coal, recovery of minerals from low-grade ores.
6. Industrial Microbiology — making
of ethanol, acetic acid, lactic acid, citric acid, glucose syrup, high-fructose syrup.
7. Medical Microbiology — helps
in the diagnostic protocol for identification of causative agents of various human ailments, and subsequent preventive
measures.
8. Pharmaceutical Microbiology — making
of life-saving drugs, ‘antibiotics’ e.g., penicillins, ampicillin,
chloramphenicol, ciprofloxacin, tetracyclines, streptomycin.
9. Soil and Agricultural Microbiology — helps
in the maintenance of a good farm land by
keeping and sustaining a reasonable and regular presence of microbes in it.
10. Waste-Treatment Microbiology —
treatment of domestic and industrial effluents or wastes by lowering the BOD*, and COD**.
Disadvantages : The apparently disadvantageous
and detrimental manner whereby the microor-ganisms may exhibit their effects
are, namely : disease-producing organisms viz.,
typhus fever caused by Rickettsia prowazekii, malaria caused by Plasmodium falciparum ; food-spoilage microbes ; and a host of
organisms that essentially deteriorate materials like optical lenses (in
microscopes and spectrophotometers), iron-pipes, and wood filings.
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