SAR of Sodium Valproate

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Chapter: Medicinal Chemistry : Anticonvulsants

The anticonvulsant activity increases with increased chain length.


SAR of Sodium Valproate


  • The anticonvulsant activity increases with increased chain length.

  • Introduction of a double bond decreases the activity.

  • Introduction of a 2° or 3° alcohol group or replacement of carbonyl or hydroxyl have no effect.

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