Pharmaceutical Drugs and Dosage: Parenteral drug products - Review questions answers
Review questions
22.1 All
parenteral products must be
A. Sterile
B. Pyrogen free
C. Isotonic
D. Sterile and pyrogen
free
E. All of the above
22.2 An
intravenous injection is desirable when
A. A rapid action is required
B. An oral
administration is ineffective
C. A prolonged action
is required
D. A and B
22.3 Which of
the following statements is TRUE and which one is FALSE?
A. Systemic drug
absorption occurs more rapidly than from oral administration compared to
intravenous administration.
B. All parenteral
products must be isotonic.
C. Filtration cannot be
used to sterilize parenteral suspensions.
D. Buffers are used in
parenteral products to stabilize the solution against pH changes.
E. Sterilization by
filtration prevents thermal stress on the product.
F. During aseptic
filtration, the solution is passed through a sterile filter of 2 μm pore size.
G. Filtration cannot be
used to sterilize parenteral suspensions.
H. Heat and radiation
sterilization methods are intended to eliminate viable microorganism from the
final products.
Answers:
22.1 D.
22.2 D. The
bacterial endotoxin test determines the level of bacterial endo-toxin only from
gram-positive bacteria. This test cannot determine the fever-producing
potential of endotoxins. Gram-negative bacte-ria do not have to be alive for
the endotoxin to produce an effect.
22.3 A. True
B. True
C. True
D. True
E. True
F. False
G. True
H.
True
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