Phenoxyacetic acid derivatives - Nonmercurial diuretics

SYNTHESIS AND DRUG PROFILE

Nonmercurial diuretics

Phenoxyacetic acid derivatives

i. Ethacrynic Acid

Synthesis

Properties and uses: It exists as a white crystalline powder that is odourless, soluble in alcohol, ether, or chloroform and in water, an aryloxyacetic acid derivative that is a potent, short-acting diuretic. It is used in the treatment of oedema caused by congestive heart failure, cirrhosis of the liver, and renal disease, including the nephrotic syndrome.