The various pharmacodynamic parameters are :
Pharmacodynamic Parameters
The various pharmacodynamic
parameters are –
It is defined as the minimum concentration of drug in plasma required to
produce the therapeutic effect. It
reflects the minimum concentration of drug at the receptor site to elicit the desired pharmacological
response. The concentration of drug below
MEC is said to be in the sub-therapeutic level.
In case of antibiotics, the term minimum inhibitory concentration (MIC)
is used. It describes the minimum concentration of antibiotic in plasma required to
kill or inhibit the growth of microorganisms.
Also called as minimum
toxic concentration (MTC), it is the
concentration of drug in plasma above
which adverse or unwanted effects are precipitated. Concentration of drug above MSC is said to be in the toxic level.
The beginning of pharmacological response is called as onset of action. It occurs when the plasma
drug concentration just exceeds the required MEC.
It is the time required for the drug to start producing pharmacological
response. It corresponds
to the time for the plasma concentration to reach MEC after administration of
drug.
The time period for which the plasma concentration of drug remains above
the MEC level is called as duration of drug action. It is
also defined as the difference between onset
time and time for the drug to decline back to MEC.
It is the maximum pharmacological response produced by the peak plasma
concentration of drug. It is also called as peak
response.
The drug concentration between MEC and MSC represents the therapeutic range. It is also known as therapeutic window.
8. Therapeutic Index
The ratio of MSC to MEC is called as therapeutic index. It is also defined as the ratio of dose
required to produce toxic or lethal effects to dose required to produce
therapeutic effect.
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