Haeme synthesis is interfered in copper deficiency. However, copper is a trace metal for man and clinical deficiency is very rare.
MISCELLANEOUS/ADJUVANT HAEMATINICS
Copper
Haeme synthesis is
interfered in copper deficiency. However,
copper is a trace metal for man and clinical deficiency is very rare. Its
routine use is, therefore, not justified. However, when copper deficiency is
demonstrated, 0.5–5 mg of copper sulphate/day may be given therapeutically; prophylactic
dose is 0.1 mg/day. It is present in some haematinic combinations.
Cobalt
It stimulates
erythropoiesis transiently, probably by inducing
tissue hypoxia → increased erythropoietin production. Cobalt deficiency is not
known in man. Moreover, it can cause hypothyroidism, angina and CHF. It should
not be prescribed.
Pyridoxine
Pyridoxine responsive anaemia is a rare entity. It is due to inherent
abnormality in haeme synthesis. Sideroblastic anaemia associated with isoniazid
and pyrazinamide (which interfere with pyridoxine metabolism and action)
therapy needs to be treated with pyridoxine. Some other sideroblastic anaemias
show partial improvement with large doses of pyridoxine. However, routine use
of pyridoxine in anaemia is wasteful.
Riboflavin
Hypoplastic anaemia occurs in riboflavin deficiency which is generally a
part of multiple deficiencies in proteincalorie malnutrition. In the absence of
specific deficiency, use of riboflavin in anaemia is of no value.
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