Cephalosporins : i. Cefoperazone ii. Cefaparole - Synthesis and Drug Profile
Synthesis
Properties and uses: Cefoperazone exists as white powder. It is a
third-generation, antipseudomonal cephalosporin that resembles piperacillin,
chemically and microbiologically. It is less active than cephalothin against
gram-positive bacteria and less active than cefamandole against most of the
enterobacteria.
Synthesis
Adverse
reactions of the cephalosporins
The
cephalosporins produce a number of adverse effects. Examples are the following:
i. Allergic manifestation: The cephalosporins should be avoided or used
with caution in individuals allergic to penicillins. When cefamandole or
cefoperazone is ingested with alcohol, a disulphiramlike effect is seen,
because these cephalosporins block the second step in alcohol oxidation, which
results in the accumulation of acetaldehyde.
ii. Bleeding: Bleeding can occur with cefemandole or ceforperazone because
of antivitamin K effects. But the administration of the vitamin overcomes this
problem.
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