A variety of mechanical, chemical and immunological stimuli are capable of releasing histamine from mast cells.
HISTAMINE RELEASERS
A
variety of mechanical, chemical and immunological stimuli are capable of
releasing histamine from mast cells.
1.
Tissue damage: trauma, stings and venoms, proteolytic enzymes, phospholipase A.
2. Antigen: antibody reaction involving IgE
antibodies.
1. Polymers like dextran,
polyvinyl pyrrolidone (PVP).
4.
Some basic drugs—tubocurarine, morphine, atropine, stilbamidine, polymyxin B,
vancomycin and even some antihistaminics directly release histamine without an
immunological reaction.
5.
Surface acting agents like Tween 80, compound 48/ 80 etc. The primary action of
these substances is release of histamine from mast cells, therefore they are
called histamine liberators. They produce an ‘anaphylactoid’ reaction—itching
and burning sensation, flushing, urticaria, fall in BP, tachycardia, headache,
colic and asthma. Most of these symptoms are controlled by a H1
antihistaminic, better still if H2 blocker is given together.
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