Drug-induced haemolytic anaemia results from a type II immune reaction in which antibodies to the drug or its metabolite(s) attack blood cells.
HAEMOLYTIC ANAEMIA
Drug-induced
haemolytic anaemia results from a type II immune reaction in which antibodies
to the drug or its metabolite(s) attack blood cells. Antigens on the cell’s
surface combine with antibody and complement to stress the cell to the point of
destruc-tion. The cell damage causes anaemia. There is an increased production
of bilirubin, although a healthy liver can excrete six times the normal load
before unconjugated bilirubin accumulates in the plasma; jaundice is therefore
mild. Severe haemolysis can result in prerenal uraemia and renal failure.
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