The applications of filtration are diverse. They may, however, be classified as either clarification or cake filtration.
Filtration
INTRODUCTION
A
student of pharmacy will have used filtration extensively in the collection of
precipitates in chemical analyses or in the preparation of parenteral fluids
and will, therefore, anticipate the definition of filtration as the removal of
solids suspended in a liquid or gas by passage through a pervious medium on
which the solids are retained. The pervious medium or septum is normally
supported on a base, and these, together with a suitable housing providing free
access of fluid to and from the septum, comprise the filter.
The
applications of filtration are diverse. They may, however, be classified as
either clarification or cake filtration.
Very
high standards of clarity are imposed during the production of pharma-ceutical
solutions. The aim may be simply the presentation of an elegant product,
although complete freedom from particulate matter is obviously nec-essary in
the manufacture of most parenteral solutions. The solids are unwanted and are
normally present in a very small concentration. Clarification may be carried
out by the use of thick media, which allow for the penetration and arrest of
particles by entrapment, impingement, and electrostatic effects. This leads to
the concept of depth filtration in which particles, perhaps a hundred times
smaller than the dimensions of the passages through the medium, are removed.
For this reason, such filters are not absolute and must be designed with
suffi-cient depth so that the probability of the passage of the smallest
particle under consideration through the filter is extremely small.
Depth
filtration differs fundamentally from the use of media in which pore size
determines the size of particle retained. Such filters may be said to be
“absolute” at a particle diameter closely related to the size of the pore, so
that there is a relatively sharp division between particles that pass the
filter and those that are retained. An analogy with sieving may be drawn for
this mechanism. The life of such filters depends on the number of pores
available for the passage of fluid. Once a particle is trapped at the entrance
to the pore, the pore’s con-tribution to the overall flow of liquid is very
much reduced. Coarse straining with a wire mesh and the membrane filter employ
this mechanism.
Sterilization
of liquids by filtration could be regarded as an extreme application of
clarification in which the complete removal of particles as small as 0.3 x 10-6
m must be ensured.
The
most common industrial application is the filtration of slurries containing a
relatively large amount of suspended solids, usually in the region of 3% to
20%. The septum acts only as a support in this operation. The actual filtration
is carried out by the solids deposited as a cake. In such cases, solids may
completely penetrate the septum until the deposition of an effective cake
occurs. Until this time, cloudy filtrate may be recycled. The physical
properties of the cake largely determine the methods employed. Often, washing and
partial drying or dewatering are integral parts of the process. Effective
discharge of the cake completes the process. The solids, the filtrate, or both
may be wanted.
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