Factors Affecting Protein-Drug Binding

FACTORS AFFECTING PROTEIN-DRUG BINDING

Factors affecting protein-drug binding can be broadly categorized as—

1. Drug related factors

a. Physicochemical characteristics of the drug

b. Concentration of drug in the body

c. Affinity of a drug for a particular binding component

2. Protein/tissue related factors

a. Physicochemical characteristics of the protein or binding agent

b. Concentration of protein or binding component

c. Number of binding sites on the binding agent

3. Drug interactions

a. Competition between drugs for the binding site (displacement interactions)

b. Competition between the drug and normal body constituents

c. Allosteric changes in protein molecule

4. Patient related factors

a. Age

b. Intersubject variations

c. Disease states