Blending is the process in which the various components of a vaccine are mixed to form a final bulk. It is undertaken in a large, closed vessel fitted with a stirrer and ports for the addition of constituents and withdrawal of the final blend.
BLENDING
Blending is the process in which the various components of a vaccine are
mixed to form a final bulk. It is undertaken in a large, closed vessel fitted
with a stirrer and ports for the addition of constituents and withdrawal of the
final blend. When bacterial vaccines are blended, the active constituents
usually need to be greatly diluted and the vessel is first charged with the
diluents, usually containing a preservative. Thiomersal has been widely used in
the past but is now being phased out and replaced by phenoxyethanol or
alternatives. A single-component final bulk is made by adding bacterial
suspension, bacterial component or concentrated toxoid in such quantity that it
is at the required concentration in the final product. A multiple-component
final bulk of a combined vaccine is made by adding each required component in
sequence. When viral vaccines are blended, the need to maintain adequate
antigenicity or infectivity may preclude dilution, and tissue culture fluids,
or concentrates made from them, are often used undiluted or, in the case of
multicomponent vaccines, merely diluted one with another. After thorough
mixing, a final bulk may be divided into a number of moderate-sized volumes to
facilitate handling.
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