Cell attachment, and subsequent biofilm formation, is a means by which pathogens can remain in a favourable environment (i.e. one where there are plenty of nutrients) without getting washed away.
BIOFILMS
Cell attachment, and
subsequent biofilm formation, is a means by which pathogens can remain in a
favourable environment (i.e. one where there are plenty of nutrients) without
getting washed away. As a consequence, bacterial cell numbers and activities
can become quite high. Biofilms can form on any surface (e.g. soft tissue, bone,
medical implants) and may contain only one or two species (e.g. Staph. aureus mediated osteomyelitis) or
more commonly several species of bacteria (e.g. dental plaque). Hence, biofilms
may be considered as a functional microbial community. Within a biofilm
intracellular signalling molecules (e.g. Nacyl
homoserine lactones) are produced that when sufficient (threshold) concentrations
are reached, upregulate bio-film specific genes. This process is known as
quorum sensing, and is responsible for the formation and maintenance of the
biofilm.
Once formed, biofilms
can be extremely difficult, if not impossible, to remove. Their size and
morphology can help protect the underlying cells, resisting physical forces or
removal, phagocytosis and penetration of toxic molecules such as antibiotics.
In addition, biofilms allow cells to live in close proximity to each other,
thereby facilitating intercellular communication and genetic exchange. Finally,
due to their profound resistance, biofilms provide foci of infection which
often can only be removed by surgery.
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